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Demethylation of induced pluripotent stem cells from type 1 diabetic patients enhances differentiation into functional pancreatic β cells

Type 1 diabetes (T1D) can be managed by transplanting either the whole pancreas or isolated pancreatic islets. However, cadaveric pancreas is scarcely available for clinical use, limiting this approach. As such, there is a great need to identify alternative sources of clinically usable pancreatic ti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Manzar, Gohar S., Kim, Eun-Mi, Zavazava, Nicholas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572901/
https://ncbi.nlm.nih.gov/pubmed/28360105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.784280
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