Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

IL-6 is a pleiotropic cytokine with complex roles in inflammation and metabolic disease. The role of IL-6 as a pro- or anti-inflammatory cytokine is still unclear. Within the pancreatic islet, IL-6 stimulates secretion of the prosurvival incretin hormone glucagon-like peptide 1 (GLP-1) by α cells an...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Linnemann, Amelia K., Blumer, Joseph, Marasco, Michelle R., Battiola, Therese J., Umhoefer, Heidi M., Han, Jee Young, Lamming, Dudley W., Davis, Dawn Belt
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572685/
https://ncbi.nlm.nih.gov/pubmed/28592636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700061RR
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