Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine

1. N-acetylcysteine (NAC) is being investigated as an antioxidant for several conditions including traumatic brain injury, but the mechanism by which it crosses membrane barriers is unknown. We sought to understand how the transporter inhibitor, probenecid, affects NAC pharmacokinetics and to evalua...

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Veröffentlicht in:Xenobiotica
Hauptverfasser: Hagos, Fanuel T., Daood, Monica J., Ocque, Jacob A., Nolin, Thomas D., Bayir, Hulya, Poloyac, Samuel M., Kochanek, Patrick M., Clark, Robert S.B., Empey, Philip E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572076/
https://ncbi.nlm.nih.gov/pubmed/27278858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2016.1187777
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