Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine

1. N-acetylcysteine (NAC) is being investigated as an antioxidant for several conditions including traumatic brain injury, but the mechanism by which it crosses membrane barriers is unknown. We sought to understand how the transporter inhibitor, probenecid, affects NAC pharmacokinetics and to evalua...

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Publicat a:Xenobiotica
Autors principals: Hagos, Fanuel T., Daood, Monica J., Ocque, Jacob A., Nolin, Thomas D., Bayir, Hulya, Poloyac, Samuel M., Kochanek, Patrick M., Clark, Robert S.B., Empey, Philip E.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572076/
https://ncbi.nlm.nih.gov/pubmed/27278858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2016.1187777
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