Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children

BACKGROUND: There are no therapies shown to improve outcome after severe traumatic brain injury (TBI) in humans, a leading cause of morbidity and mortality. We sought to verify brain exposure of the systemically administered antioxidant N-acetylcysteine (NAC) and the synergistic adjuvant probenecid,...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Clark, Robert S. B., Empey, Philip E., Bayır, Hülya, Rosario, Bedda L., Poloyac, Samuel M., Kochanek, Patrick M., Nolin, Thomas D., Au, Alicia K., Horvat, Christopher M., Wisniewski, Stephen R., Bell, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501440/
https://ncbi.nlm.nih.gov/pubmed/28686657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180280
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