Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine

1. N-acetylcysteine (NAC) is being investigated as an antioxidant for several conditions including traumatic brain injury, but the mechanism by which it crosses membrane barriers is unknown. We sought to understand how the transporter inhibitor, probenecid, affects NAC pharmacokinetics and to evalua...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Xenobiotica
Päätekijät: Hagos, Fanuel T., Daood, Monica J., Ocque, Jacob A., Nolin, Thomas D., Bayir, Hulya, Poloyac, Samuel M., Kochanek, Patrick M., Clark, Robert S.B., Empey, Philip E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572076/
https://ncbi.nlm.nih.gov/pubmed/27278858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2016.1187777
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