Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine

1. N-acetylcysteine (NAC) is being investigated as an antioxidant for several conditions including traumatic brain injury, but the mechanism by which it crosses membrane barriers is unknown. We sought to understand how the transporter inhibitor, probenecid, affects NAC pharmacokinetics and to evalua...

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Detalhes bibliográficos
Publicado no:Xenobiotica
Main Authors: Hagos, Fanuel T., Daood, Monica J., Ocque, Jacob A., Nolin, Thomas D., Bayir, Hulya, Poloyac, Samuel M., Kochanek, Patrick M., Clark, Robert S.B., Empey, Philip E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572076/
https://ncbi.nlm.nih.gov/pubmed/27278858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2016.1187777
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