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The role of conserved surface hydrophobic residues in the carbapenemase activity of the class D β-lactamases
Carbapenem-hydrolyzing class D β-lactamases (CHDLs) produce resistance to the last-resort carbapenem antibiotics and render these drugs ineffective for the treatment of life-threatening infections. Here, it is shown that among the clinically important CHDLs, OXA-143 produces the highest levels of re...
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| Udgivet i: | Acta Crystallogr D Struct Biol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
International Union of Crystallography
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5571744/ https://ncbi.nlm.nih.gov/pubmed/28777084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798317008671 |
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