Role of the Conserved Disulfide Bridge in Class A Carbapenemases

Some members of the class A β-lactamase family are capable of conferring resistance to the last resort antibiotics, carbapenems. A unique structural feature of these clinically important enzymes, collectively referred to as class A carbapenemases, is a disulfide bridge between invariant Cys(69) and...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Smith, Clyde A., Nossoni, Zahra, Toth, Marta, Stewart, Nichole K., Frase, Hilary, Vakulenko, Sergei B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063999/
https://ncbi.nlm.nih.gov/pubmed/27590339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749648
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