In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus fumigatus Infection in Immunocompromised Mice

PC945 is a novel triazole optimized for lung delivery, and the objective of this study is to determine the effects of intranasally dosed PC945 on Aspergillus fumigatus infection and associated biomarkers in immunocompromised mice. PC945, posaconazole, or voriconazole was administered intranasally on...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Kimura, Genki, Nakaoki, Takahiro, Colley, Thomas, Rapeport, Garth, Strong, Pete, Ito, Kazuhiro, Kizawa, Yasuo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571324/
https://ncbi.nlm.nih.gov/pubmed/28630185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00124-17
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