Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase (sEH) degrades anti-inflammatory epoxyeicosatrieno...

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Pubblicato in:Sci Rep
Autori principali: Garscha, Ulrike, Romp, Erik, Pace, Simona, Rossi, Antonietta, Temml, Veronika, Schuster, Daniela, König, Stefanie, Gerstmeier, Jana, Liening, Stefanie, Werner, Markus, Atze, Heiner, Wittmann, Sandra, Weinigel, Christina, Rummler, Silke, Scriba, Gerhard K., Sautebin, Lidia, Werz, Oliver
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571211/
https://ncbi.nlm.nih.gov/pubmed/28839250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09795-w
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