Synthesis, Biological Evaluation and Structure–Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors

[Image: see text] A series of derivatives of the potent dual soluble epoxide hydrolase (sEH)/5-lipoxygenase-activating protein (FLAP) inhibitor diflapolin was designed, synthesized, and characterized by (1)H NMR, (13)C NMR, and elemental analysis. These novel compounds were biologically evaluated fo...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Vieider, Lisa, Romp, Erik, Temml, Veronika, Fischer, Jana, Kretzer, Christian, Schoenthaler, Martin, Taha, Abdulla, Hernández-Olmos, Victor, Sturm, Sonja, Schuster, Daniela, Werz, Oliver, Garscha, Ulrike, Matuszczak, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331193/
https://ncbi.nlm.nih.gov/pubmed/30655948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00415
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