Targeted Genome Replacement via Homology-directed Repair in Non-dividing Cardiomyocytes

Although high-throughput sequencing can elucidate the genetic basis of hereditary cardiomyopathy, direct interventions targeting pathological mutations have not been established. Furthermore, it remains uncertain whether homology-directed repair (HDR) is effective in non-dividing cardiomyocytes. Her...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Ishizu, Takamaru, Higo, Shuichiro, Masumura, Yuki, Kohama, Yasuaki, Shiba, Mikio, Higo, Tomoaki, Shibamoto, Masato, Nakagawa, Akito, Morimoto, Sachio, Takashima, Seiji, Hikoso, Shungo, Sakata, Yasushi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571012/
https://ncbi.nlm.nih.gov/pubmed/28839205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09716-x
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