The hepatocyte-specific HNF4α/miR-122 pathway contributes to iron overload–mediated hepatic inflammation

Hepatic iron overload (IO) is a major complication of transfusional therapy. It was generally thought that IO triggers substantial inflammatory responses by producing reactive oxygen species in hepatic macrophages. Recently, a decrease in microRNA-122 (miR-122) expression was observed in a genetic k...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Li, Min, Tang, Yuxiao, Wu, Lusha, Mo, Fengfeng, Wang, Xin, Li, Hongxia, Qi, Ruirui, Zhang, Hongwei, Srivastava, Arun, Ling, Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570677/
https://ncbi.nlm.nih.gov/pubmed/28655781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-12-755967
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