Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors

Neuronal nitric oxide synthase (nNOS) is a target for development of anti-neurodegenerative agents. Most nNOS inhibitors mimic L-arginine and have poor bioavailability. 2-Aminoquinolines showed promise as bioavailable nNOS inhibitors, but suffered from low human nNOS inhibition, low selectivity vers...

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Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Pensa, Anthony V., Cinelli, Maris A., Li, Huiying, Chreifi, Georges, Mukherjee, Paramita, Roman, Linda J., Martásek, Pavel, Poulos, Thomas L., Silverman, Richard B.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570656/
https://ncbi.nlm.nih.gov/pubmed/28776992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00835
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