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Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors
Neuronal nitric oxide synthase (nNOS) is a target for development of anti-neurodegenerative agents. Most nNOS inhibitors mimic L-arginine and have poor bioavailability. 2-Aminoquinolines showed promise as bioavailable nNOS inhibitors, but suffered from low human nNOS inhibition, low selectivity vers...
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| Foilsithe in: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2017
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5570656/ https://ncbi.nlm.nih.gov/pubmed/28776992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00835 |
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