Neonatal mouse hippocampus: Phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of rapamycin (mTOR) signaling

BACKGROUND: Phlebotomy-induced anemia (PIA) is common in premature infants and affects neurodevelopment. PIA alters hippocampal metabolism in neonatal mice through tissue hypoxia and iron deficiency. The mammalian target of rapamycin (mTOR) pathway senses the status of critical metabolites (e.g., ox...

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Detalhes bibliográficos
Publicado no:Pediatr Res
Main Authors: Wallin, Diana J., Zamora, Tara G., Alexander, Michelle, Ennis, Kathleen M., Tran, Phu V., Georgieff, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570638/
https://ncbi.nlm.nih.gov/pubmed/28399115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2017.88
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