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Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses
Conflicts between transcription and replication are a potent source of DNA damage. Co-transcriptional R-loops could aggravate such conflicts by creating an additional barrier to replication fork progression. Here, we use a defined episomal system to investigate how conflict orientation and R-loop fo...
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| Publicado en: | Cell |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5570545/ https://ncbi.nlm.nih.gov/pubmed/28802045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.043 |
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