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The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

Accurate DNA replication and DNA repair are crucial for the maintenance of genome stability, and it is generally accepted that failure of these processes is a major source of DNA damage in cells. Intriguingly, recent evidence suggests that DNA damage is more likely to occur at genomic loci with high...

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Detalhes bibliográficos
Main Authors: Hamperl, Stephan, Cimprich, Karlene A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051866/
https://ncbi.nlm.nih.gov/pubmed/24746923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.03.023
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