Loss of the chromatin modifier Kdm2aa causes Braf(V600E)-independent spontaneous melanoma in zebrafish

KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanoma...

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Vydáno v:PLoS Genet
Hlavní autoři: Scahill, Catherine M., Digby, Zsofia, Sealy, Ian M., Wojciechowska, Sonia, White, Richard J., Collins, John E., Stemple, Derek L., Bartke, Till, Mathers, Marie E., Patton, E. Elizabeth, Busch-Nentwich, Elisabeth M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570503/
https://ncbi.nlm.nih.gov/pubmed/28806732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006959
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