Loss of the chromatin modifier Kdm2aa causes Braf(V600E)-independent spontaneous melanoma in zebrafish

KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanoma...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Scahill, Catherine M., Digby, Zsofia, Sealy, Ian M., Wojciechowska, Sonia, White, Richard J., Collins, John E., Stemple, Derek L., Bartke, Till, Mathers, Marie E., Patton, E. Elizabeth, Busch-Nentwich, Elisabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570503/
https://ncbi.nlm.nih.gov/pubmed/28806732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006959
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