Loss of the chromatin modifier Kdm2aa causes Braf(V600E)-independent spontaneous melanoma in zebrafish

KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes widespread transcriptional disruption and leads to spontaneous melanoma...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Scahill, Catherine M., Digby, Zsofia, Sealy, Ian M., Wojciechowska, Sonia, White, Richard J., Collins, John E., Stemple, Derek L., Bartke, Till, Mathers, Marie E., Patton, E. Elizabeth, Busch-Nentwich, Elisabeth M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570503/
https://ncbi.nlm.nih.gov/pubmed/28806732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006959
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker