The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish

Background: Mutations in proteins involved in telomere maintenance lead to a range of human diseases, including dyskeratosis congenita, idiopathic pulmonary fibrosis and cancer. Telomerase functions to add telomeric repeats back onto the ends of chromosomes, however non-canonical roles of components...

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Veröffentlicht in:Wellcome Open Res
Hauptverfasser: Scahill, Catherine M., Digby, Zsofia, Sealy, Ian M., White, Richard J., Wali, Neha, Collins, John E., Stemple, Derek L., Busch-Nentwich, Elisabeth M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: F1000 Research Limited 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5840683/
https://ncbi.nlm.nih.gov/pubmed/29568807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.12530.2
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