Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins

Protein-based methods of siRNA delivery are capable of uniquely specific targeting, but are limited by technical challenges such as low potency or poor biophysical properties. Here, we engineered a series of ultra-high affinity siRNA binders based on the viral protein p19 and developed them into siR...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Yang, Nicole J., Kauke, Monique J., Sun, Fangdi, Yang, Lucy F., Maass, Katie F., Traxlmayr, Michael W., Yu, Yao, Xu, Yingda, Langer, Robert S., Anderson, Daniel G., Wittrup, K. Dane
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570165/
https://ncbi.nlm.nih.gov/pubmed/28641400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx546
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