Removal of dsRNA byproducts using affinity chromatography

Double-stranded RNA (dsRNA) molecules are immunogenic byproducts of in vitro transcription of single-stranded RNA (ssRNA). Removal of dsRNA from ssRNA is difficult because the byproducts have similar sizes, sequences, and charges to the desired ssRNA. Here, we describe a dsRNA-specific affinity resi...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Nathaniel E. Clark, Mateusz Kozarski, Sinem Demirel Asci, Jurgen Van den Heuvel, Matt R. Schraut, Roger A. Winters, Kelley Kearns, Thomas C. Scanlon, Senne Dillen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2025-06-01
Sarja:Molecular Therapy: Nucleic Acids
Aiheet:
MT: Oligonucleotides: Therapies and Applications
double-stranded RNA
messenger RNA
circular RNA
self-amplifying RNA
in vitro transcription
Linkit:http://www.sciencedirect.com/science/article/pii/S2162253125001039
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