A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function

The transcription factor c-Myb is involved in early differentiation and proliferation of haematopoietic cells, where it operates as a regulator of self-renewal and multi-lineage differentiation. Deregulated c-Myb plays critical roles in leukaemias and other human cancers. Due to its role as a master...

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Udgivet i:Nucleic Acids Res
Main Authors: Fuglerud, Bettina M., Lemma, Roza B., Wanichawan, Pimthanya, Sundaram, Arvind Y. M., Eskeland, Ragnhild, Gabrielsen, Odd S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Gene regulation, Chromatin and Epigenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570105/
https://ncbi.nlm.nih.gov/pubmed/28472346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx364
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