Lysosomal processing of progranulin

BACKGROUND: Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to the lysosome and important for proper lysosome function. However, the metabolism...

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Bibliografiske detaljer
Udgivet i:Mol Neurodegener
Main Authors: Zhou, Xiaolai, Paushter, Daniel H., Feng, Tuancheng, Sun, Lirong, Reinheckel, Thomas, Hu, Fenghua
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569495/
https://ncbi.nlm.nih.gov/pubmed/28835281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0205-9
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