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Lysosomal processing of progranulin
BACKGROUND: Mutations resulting in progranulin (PGRN) haploinsufficiency cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. PGRN is localized to the lysosome and important for proper lysosome function. However, the metabolism...
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| Publicado en: | Mol Neurodegener |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5569495/ https://ncbi.nlm.nih.gov/pubmed/28835281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0205-9 |
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