A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2.

The epidermal growth factor (EGF) receptor (EGFR) and the erbB-2 gene product, gp185erbB-2, exhibit distinct abilities to stimulate mitogenesis in different target cells. By using chimeric molecules between these two receptors, we have previously shown that their intracellular juxtamembrane regions...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Di Fiore, P P, Helin, K, Kraus, M H, Pierce, J H, Artrip, J, Segatto, O, Bottaro, D P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556903/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1356764/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05486.x
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