The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

Lignende værker

• The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.
  af: Segatto, O, et al.
  Udgivet: (1991)
• The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.
  af: Fazioli, F, et al.
  Udgivet: (1991)
• Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.
  af: Segatto, O, et al.
  Udgivet: (1988)
• A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2.
  af: Di Fiore, P P, et al.
  Udgivet: (1992)
• Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors.
  af: Alimandi, M, et al.
  Udgivet: (1997)