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The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.

The erbB-2 gene product, gp185erbB-2, displays a potent transforming effect when overexpressed in NIH 3T3 cells. In addition, it possesses constitutively high levels of tyrosine kinase activity in the absence of exogenously added ligand. In this study, we demonstrate that its carboxy-terminal domain...

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Publicado no:Mol Cell Biol
Principais autores: Di Fiore, P P, Segatto, O, Lonardo, F, Fazioli, F, Pierce, J H, Aaronson, S A
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360635/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2188097/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.6.2749-2756.1990
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