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The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.

The erbB-2 gene product, gp185erbB-2, unlike the structurally related epidermal growth factor (EGF) receptor (EGFR), exhibits constitutive kinase and transforming activity. We used a chimeric EGFR/erbB-2 expression vector to compare the mitogenic signaling pathway of the erbB-2 kinase with that of t...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Fazioli, F, Kim, U H, Rhee, S G, Molloy, C J, Segatto, O, Di Fiore, P P
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1991
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359891/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1672440/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.4.2040
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