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The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.

The erbB-2 gene product, gp185erbB-2, unlike the structurally related epidermal growth factor (EGF) receptor (EGFR), exhibits constitutive kinase and transforming activity. We used a chimeric EGFR/erbB-2 expression vector to compare the mitogenic signaling pathway of the erbB-2 kinase with that of t...

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Tallennettuna:
Julkaisussa:Mol Cell Biol
Päätekijät: Fazioli, F, Kim, U H, Rhee, S G, Molloy, C J, Segatto, O, Di Fiore, P P
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 1991
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359891/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1672440/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.4.2040-2048.1991
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