A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2.

Benzer Materyaller

• The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction.
  Yazar:: Segatto, O, ve diğerleri
  Baskı/Yayın Bilgisi: (1991)
• The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.
  Yazar:: Fazioli, F, ve diğerleri
  Baskı/Yayın Bilgisi: (1991)
• Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors.
  Yazar:: Alimandi, M, ve diğerleri
  Baskı/Yayın Bilgisi: (1997)
• Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.
  Yazar:: Fedi, P, ve diğerleri
  Baskı/Yayın Bilgisi: (1994)
• The carboxy-terminal domains of erbB-2 and epidermal growth factor receptor exert different regulatory effects on intrinsic receptor tyrosine kinase function and transforming activity.
  Yazar:: Di Fiore, P P, ve diğerleri
  Baskı/Yayın Bilgisi: (1990)