Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

Pulmonary fibrosis is a scarring of the lungs that can arise from radiation injury, drug toxicity, environmental or genetic causes, and for unknown reasons [idiopathic pulmonary fibrosis (IPF)]. Overexpression of collagen is a hallmark of organ fibrosis. Here, we describe a peptide-based PET probe (...

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Vydáno v:Sci Transl Med
Hlavní autoři: Désogère, Pauline, Tapias, Luis F., Hariri, Lida P., Rotile, Nicholas J., Rietz, Tyson A., Probst, Clemens K., Blasi, Francesco, Day, Helen, Mino-Kenudson, Mari, Weinreb, Paul, Violette, Shelia M., Fuchs, Bryan C., Tager, Andrew M., Lanuti, Michael, Caravan, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568793/
https://ncbi.nlm.nih.gov/pubmed/28381537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf4696
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