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A High-Throughput Process for the Solid-Phase Purification of Synthetic DNA Sequences

An efficient process for the purification of synthetic phosphorothioate and native DNA sequences is presented. The process is based on the use of an aminopropylated silica gel support functionalized with aminooxyalkyl functions to enable capture of DNA sequences through an oximation reaction with th...

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Détails bibliographiques
Publié dans:Curr Protoc Nucleic Acid Chem
Auteurs principaux: Grajkowski, Andrzej, Cieślak, Jacek, Beaucage, Serge L.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568675/
https://ncbi.nlm.nih.gov/pubmed/28628204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpnc.31
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