The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.

Poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30) is a zinc finger DNA-binding protein involved in DNA repair processes in eukaryotes. By deletion and extensive site-directed mutagenesis, its DNA-binding domain fused to the N-terminus of beta-galactosidase was shown to contain a nuclear localization s...

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Pubblicato in:	EMBO J
Autori principali:	Schreiber, V, Molinete, M, Boeuf, H, de Murcia, G, Ménissier-de Murcia, J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556860/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1505517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05404.x
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