Загрузка...

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in turn, triggers the synthesis of polymers of ADP-ribose linked to nuclear proteins during DNA repair. T...

Полное описание

Сохранить в:

Библиографические подробности
Опубликовано в: :	EMBO J
Главные авторы:	Molinete, M, Vermeulen, W, Bürkle, A, Ménissier-de Murcia, J, Küpper, J H, Hoeijmakers, J H, de Murcia, G
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 1993
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413432/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8491199/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05859.x
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

Схожие документы