Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in turn, triggers the synthesis of polymers of ADP-ribose linked to nuclear proteins during DNA repair. T...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Molinete, M, Vermeulen, W, Bürkle, A, Ménissier-de Murcia, J, Küpper, J H, Hoeijmakers, J H, de Murcia, G
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1993
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413432/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8491199/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05859.x
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