Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

The zinc-finger DNA-binding domain (DBD) of poly (ADP-ribose) polymerase (PARP, EC 2.4.2.30) specifically recognizes DNA strand breaks induced by various DNA-damaging agents in eukaryotes. This, in turn, triggers the synthesis of polymers of ADP-ribose linked to nuclear proteins during DNA repair. T...

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Bibliographic Details
Main Authors:	Molinete, M, Vermeulen, W, Bürkle, A, Ménissier-de Murcia, J, Küpper, J H, Hoeijmakers, J H, de Murcia, G
Format:	Artigo
Language:	Inglês
Published:	1993
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC413432/ https://ncbi.nlm.nih.gov/pubmed/8491199
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Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

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