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Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma

Traditional structure and ligand based virtual screening approaches rely on the availability of structural and ligand binding information. To overcome this limitation, hybrid approaches were developed that relied on extraction of ligand binding information from proteins sharing similar folds and hen...

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Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Autores principales: Srinivasan, Bharath, Tonddast-Navaei, Sam, Skolnick, Jeffrey
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568477/
https://ncbi.nlm.nih.gov/pubmed/28739043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.07.035
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