Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase

Eitemau Tebyg

• Insights into the slow-onset tight-binding inhibition of Escherichia coli Dihydrofolate Reductase: detailed mechanistic characterization of Pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors
  gan: Srinivasan, Bharath, et al.
  Cyhoeddwyd: (2015)
• Chemical Space of Escherichia coli Dihydrofolate Reductase Inhibitors: New Approaches for Discovering Novel Drugs for Old Bugs
  gan: Srinivasan, Bharath, et al.
  Cyhoeddwyd: (2018)
• Rational design of novel allosteric dihydrofolate reductase inhibitors showing antibacterial-effects on drug-resistant E. coli escape-variants
  gan: Srinivasan, Bharath, et al.
  Cyhoeddwyd: (2017)
• On the importance of COmposite Protein multiple LIGand (COLIG) Interactions in Protein Pockets
  gan: Tonddast-Navaei, Sam, et al.
  Cyhoeddwyd: (2016)
• Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma
  gan: Srinivasan, Bharath, et al.
  Cyhoeddwyd: (2017)