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On the importance of COmposite Protein multiple LIGand (COLIG) Interactions in Protein Pockets

Conventional small molecule drug-discovery approaches target protein pockets. However, the limited number of geometrically distinct pockets leads to widespread promiscuity and deleterious side-effects. Here, the idea of COmposite protein LIGands (COLIG) that interact with each other as well as the p...

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Dades bibliogràfiques
Publicat a:J Comput Chem
Autors principals: Tonddast-Navaei, Sam, Srinivasan, Bharath, Skolnick, Jeffrey
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403588/
https://ncbi.nlm.nih.gov/pubmed/27864975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.24523
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