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Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function

Coincidence of the properties of ligand binding pockets in native proteins with those in proteins generated by computer simulations without selection for function shows that pockets are a generic protein feature and the number of distinct pockets is small. Similar pockets occur in unrelated protein...

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Bibliografiska uppgifter
I publikationen:Bioorg Med Chem Lett
Huvudupphovsmän: Skolnick, Jeffrey, Gao, Mu, Roy, Ambrish, Srinivasan, Bharath, Zhou, Hongyi
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593502/
https://ncbi.nlm.nih.gov/pubmed/25690787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.059
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