Llwytho...

Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function

Coincidence of the properties of ligand binding pockets in native proteins with those in proteins generated by computer simulations without selection for function shows that pockets are a generic protein feature and the number of distinct pockets is small. Similar pockets occur in unrelated protein...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioorg Med Chem Lett
Prif Awduron: Skolnick, Jeffrey, Gao, Mu, Roy, Ambrish, Srinivasan, Bharath, Zhou, Hongyi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593502/
https://ncbi.nlm.nih.gov/pubmed/25690787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.059
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