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Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function
Coincidence of the properties of ligand binding pockets in native proteins with those in proteins generated by computer simulations without selection for function shows that pockets are a generic protein feature and the number of distinct pockets is small. Similar pockets occur in unrelated protein...
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| 出版年: | Bioorg Med Chem Lett |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4593502/ https://ncbi.nlm.nih.gov/pubmed/25690787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.059 |
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