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Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function

Coincidence of the properties of ligand binding pockets in native proteins with those in proteins generated by computer simulations without selection for function shows that pockets are a generic protein feature and the number of distinct pockets is small. Similar pockets occur in unrelated protein...

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Bibliographische Detailangaben
Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Skolnick, Jeffrey, Gao, Mu, Roy, Ambrish, Srinivasan, Bharath, Zhou, Hongyi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593502/
https://ncbi.nlm.nih.gov/pubmed/25690787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.059
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