5- or/and 20-O-Alkyl-2,3-dehydrosilybins: Synthesis and biological profiles on prostate cancer cell models

To investigate the effects of alkylation at 5-OH and 20-OH of 2,3-dehydrosilybin on prostate cancer cell proliferation, the synthetic approaches to 5- or/and 20-O-alkyl-2,3-dehydrosilybins, through a multi-step sequence from commercially available silybin, have been successfully developed. The first...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Vue, Bao, Zhang, Xiaojie, Lee, Timmy, Nair, Nandini, Zhang, Sheng, Chen, Guanglin, Zhang, Qiang, Zheng, Shilong, Wang, Guangdi, Chen, Qiao-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568090/
https://ncbi.nlm.nih.gov/pubmed/28756013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.07.035
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