Silibinin Derivatives as Anti-Prostate Cancer Agents: Synthesis and Cell-Based Evaluations

This study aims to systematically explore the alkylation effect of 7-OH in silibinin and 2,3-dehydrosilibinin on the antiproliferative potency toward three prostate cancer cell lines. Eight 7-O-alkylsilibinins, eight 7-O-alkyl-2,3-dehydrosilibinins, and eight 3,7-O-dialkyl-2,3-dehydrosilibinins have...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Vue, Bao, Zhang, Sheng, Zhang, Xiaojie, Parisis, Konstantinos, Zhang, Qiang, Zheng, Shilong, Wang, Guangdi, Chen, Qiao-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4738075/
https://ncbi.nlm.nih.gov/pubmed/26748997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.12.041
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