Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer

Apomab, a fully human agonistic DR5 monoclonal antibody, triggers apoptosis through activation of the extrinsic apoptotic signaling pathway. In this study, we assessed the cytotoxic effect of Apomab in vitro and evaluated its antitumor activity in murine models of breast cancer development and progr...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Zinonos, Irene, Labrinidis, Agatha, Lee, Michelle, Liapis, Vasilios, Hay, Shelley, Ponomarev, Vladimir, Diamond, Peter, Zannettino, Andrew C.W., Findlay, David M., Evdokiou, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568046/
https://ncbi.nlm.nih.gov/pubmed/19808976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0745
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