Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum.

A chloroquine resistant cloned isolate of Plasmodium falciparum, FAC8, which carries an amplification in the pfmdr1 gene was selected for high-level chloroquine resistance, resulting in a cell line resistant to a 10-fold higher concentration of chloroquine. These cells were found to have lost the am...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Barnes, D A, Foote, S J, Galatis, D, Kemp, D J, Cowman, A F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1992
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556790/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1353446/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05378.x
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