Role of Pfmdr1 in In Vitro Plasmodium falciparum Susceptibility to Chloroquine, Quinine, Monodesethylamodiaquine, Mefloquine, Lumefantrine, and Dihydroartemisinin

The involvement of Pfmdr1 (Plasmodium falciparum multidrug resistance 1) polymorphisms in antimalarial drug resistance is still debated. Here, we evaluate the association between polymorphisms in Pfmdr1 (N86Y, Y184F, S1034C, N1042D, and D1246Y) and Pfcrt (K76T) and in vitro responses to chloroquine...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wurtz, Nathalie, Fall, Bécaye, Pascual, Aurélie, Fall, Mansour, Baret, Eric, Camara, Cheikhou, Nakoulima, Aminata, Diatta, Bakary, Fall, Khadidiatou Ba, Mbaye, Pape Saliou, Diémé, Yaya, Bercion, Raymond, Wade, Boubacar, Pradines, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249527/
https://ncbi.nlm.nih.gov/pubmed/25199781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03494-14
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