Role of Pfmdr1 in In Vitro Plasmodium falciparum Susceptibility to Chloroquine, Quinine, Monodesethylamodiaquine, Mefloquine, Lumefantrine, and Dihydroartemisinin

The involvement of Pfmdr1 (Plasmodium falciparum multidrug resistance 1) polymorphisms in antimalarial drug resistance is still debated. Here, we evaluate the association between polymorphisms in Pfmdr1 (N86Y, Y184F, S1034C, N1042D, and D1246Y) and Pfcrt (K76T) and in vitro responses to chloroquine...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Wurtz, Nathalie, Fall, Bécaye, Pascual, Aurélie, Fall, Mansour, Baret, Eric, Camara, Cheikhou, Nakoulima, Aminata, Diatta, Bakary, Fall, Khadidiatou Ba, Mbaye, Pape Saliou, Diémé, Yaya, Bercion, Raymond, Wade, Boubacar, Pradines, Bruno
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249527/
https://ncbi.nlm.nih.gov/pubmed/25199781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03494-14
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