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Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine.

Two chloroquine-resistant cloned isolates of Plasmodium falciparum were subjected to mefloquine selection to test if this resulted in alterations in chloroquine sensitivity and amplification of the pfmdr1 gene. The mefloquine-resistant lines derived by this selection were shown to have amplified and...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Cowman, A F, Galatis, D, Thompson, J K
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1994
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521470/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8302844/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.3.1143
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