Autocrine feedback loop involving IL-6 family member LIF, LIF receptor and STAT4 drives sustained fibroblast production of inflammatory mediators

Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyse...

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Enregistré dans:
Détails bibliographiques
Publié dans:Immunity
Auteurs principaux: Nguyen, Hung N., Noss, Erika H., Mizoguchi, Fumitaka, Huppertz, Christine, Wei, Kevin S., Watts, Gerald F. M., Brenner, Michael B.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567864/
https://ncbi.nlm.nih.gov/pubmed/28228280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.01.004
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