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Cadherin-11 engagement modulates matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts

OBJECTIVE: Cadherin-11 is a homophilic cell-to-cell adhesion molecule expressed on joint synovial fibroblasts. Absence of cadherin-11 in a mouse rheumatoid arthritis (RA) model led to striking reductions in cartilage erosion. Matrix metalloproteinases (MMPs) are enzymes expressed by synovial fibrobl...

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Detalhes bibliográficos
Publicado no:Arthritis Rheum
Main Authors: Noss, Erika H., Chang, Sook Kyung, Watts, Gerald F.M., Brenner, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507176/
https://ncbi.nlm.nih.gov/pubmed/22127696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30630
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