CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts

The role of stromal fibroblasts in chronic inflammation is unfolding. In rheumatoid arthritis, leukocyte-derived cytokines TNF and IL-17A work together, activating fibroblasts to become a dominant source of the hallmark cytokine IL-6. However, IL-17A alone has minimal effect on fibroblasts. To ident...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Slowikowski, Kamil, Nguyen, Hung N., Noss, Erika H., Simmons, Daimon P., Mizoguchi, Fumitaka, Watts, Gerald F. M., Gurish, Michael F., Brenner, Michael B., Raychaudhuri, Soumya
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071902/
https://ncbi.nlm.nih.gov/pubmed/32079724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912702117
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